FAQ

Yes, the data is hosted on a fully secure health data warehouse. In addition, we do not sell your data or your patients' data to third parties.
For more information on our data protection policy see our Privacy Policy

The use of the Predigraft application requires you to provide certain personal data in order to operate the application.
When using the application, you may be asked to provide us with your full name, date of birth, gender, title, language, email address and telephone number in order to:

• Establish a regular means of communication with a given healthcare professional (identification through email address or telephone number)
• Establish a regular means of communication with a given healthcare professional (identification through email address or telephone number)
• Communicate with you for information purposes about the use of the application itself, in case of security information related to the application, and may be used for commercial purposes
• To manage technical support

The estimated GFR value must be between 0 and 300. Above 120, a message informs you that the iBox calculation will be done with a GFR of 120
The limit of 120 mL/min/1.73m² for calculating the iBox result has been established because the calculation of the iBox probabilities and the expected survival benefit at 3, 5, 7 years are unchanged above 120 mL/min/1.73m².

The Monitoring/Risk Assessment item lists the patient's iBox reports. You can click on one of the rows in the list to access the iBox report.

The date corresponds to the date entered in the "DFG-e" step when creating a report.
The pictograms correspond to :

Biological data: This icon is always present. It corresponds to the first two mandatory steps of the creation of a report: GFR-e and Proteinuria.

Graft specific anti-HLA antibody (DSA) data. This icon is present if you have entered DSA data when creating the report.

Histology data: This icon is present if you have entered data in Histology when creating the report.

You have just received an iBox alert on one of your patient's profile, what does this mean?
The iBox alert is a notification of a 5-point decrease in the 7-year graft survival percentage from the highest percentage in the year or from the last biopsy.
A 5% decrease in the probability of 7-year graft survival is a sign of patient instability and is associated with more renal graft complications/damage. By sending you a notification, the aim is to give you additional information in the management of your patient and the therapeutic decision.
This alert is generated automatically, whether the data is entered manually or automatically in the iBox.

Use Case :
In practice, Predigraft's iBox alert is intended to be used as a follow-up tool after a kidney transplant. Following an iBox alert, the doctor can, for example, prescribe additional examinations: Doppler ultrasound of the graft, examination for pyelonephritis of the graft, search for DSA, or even biopsy of the graft. This alert may also lead you to adjust the frequency of follow-up of your patients according to changes in their graft survival percentage.

Below is an example of a case where the iBox alert would have allowed an intervention by the health professional.

Patient profile :
36 year old patient - Alport syndrome - Transplanted 3.3 years ago - Last biopsy 1.3 years ago: normal, no rejection

Evolution of proteinuria and creatinine since the last biopsy:

Insidious increases in creatinine and proteinuria can be observed, but relatively small between each measurement. These progressions did not lead to medical intervention.
The patient had a biopsy on day 500 (following the development of proteinuria), which may have shown antibody-mediated rejection.

Evolution of the 7-year survival probability of the kidney graft since the last biopsy:

An iBox alert would have been triggered on day 100 (iBox at 7 years decreases by 10%).
This could have triggered an intervention by the health professional.

• Apilife is a medical device intended to be used as a predictive tool to inform healthcare professionals about the probability of survival of kidney allografts after renal transplantation. These probabilities, along with all available standard clinical data, help to describe the status of the allograft and provide additional information in the decision about patient care and treatment. Specifically, Predigraft provides allograft survival probabilities at +3 / +5 / +7 years after evaluation, based on a combination of clinical, biological and histological parameters (iBox technology). In addition, it allows the transplant follow-up team to consolidate all patient follow-up information in one place to avoid loss of information and to improve data transmission between the various parties involved with the patient.
• Apilife is also intended to be used as a remote monitoring tool after kidney transplantation to facilitate communication between the patient and their nephrologist by providing a system of customisable alerts. The patient can send clinical data such as weight and blood pressure, send documents such as biological analysis results or access the secure messaging system with the follow-up team. Finally, they have access to fun and comprehensive therapeutic education content.

Predigraft is being developed using integrative BOX technology (iBox).

The iBox predicts the likelihood that the graft will still be functional at 3 years, 5 years and 7 years after assessment by healthcare staff.

Predigraft provides a detailed view of individual patient risks and allows for personalised treatment, aimed at prolonging allograft survival and improving patient well-being.

If you want more information about your predictive score, talk to your nephrologist.

Your nephrologist has asked you to weigh yourself regularly. A rapid change in weight indicates a change in the amount of water in your body.

• An increase in weight if you do not eliminate enough water, even before you have any symptoms (swollen ankles or oedema, difficulty breathing, etc.)
• Weight loss if you have eliminated too much water, either by urinating (overdose of your diuretic treatment), or in the event of diarrhoea or profuse sweating (extreme heat, fever, intensive sport....).

• It's pretty easy after all because you step on the scale and your weight, in kilograms (kg), is displayed within seconds.
• Weigh yourself under similar conditions each time.
• The scale display shows your weight in kilograms (e.g. 70 kg).

The important thing is to always weigh yourself under the same conditions (dressed or naked, before or after eating, in the morning or in the evening...)

To ensure optimal remote monitoring by your nephrologist, you should at least weigh yourself every 15 days and report the values in your Apilife account.

To ensure optimal remote monitoring by your nephrologist, you should at least take your blood pressure every two weeks and report it in your Apilife account.

• Avoid caffeine or physical exertion just before the measurement. Sit comfortably in a chair, in a quiet place, for 5 minutes.
• Place your arm slightly bent on a table, with your elbow at heart level (chest level).
• Place the cuff on your bare arm, observing the tapering direction indicated on the cuff. Switch on the device: the cuff inflates and deflates automatically. Do not talk, move or clench your fist during the measurement.
• The monitor's display shows two values in millimetres of mercury (mm Hg). The first, higher number is the systolic blood pressure (measured when the heart contracts to push blood through the arteries). The second number is the diastolic blood pressure (measured when the heart is relaxed and fills with blood).
• If possible, take 3 measurements and keep the last one.

Caution : if you have a functional arteriovenous fistula,
take your blood pressure on the other arm

Normal blood pressure contributes to a better long-term survival of your graft and a reduction in cardiovascular risks.

Apilife does not replace consultations with your nephrologist but allows for more regular follow-up.